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39-47_0408PP_aan het Rot_CME.indd

Conventional pharmacologic treatments for major depressive disorder (MDD) generally take several weeks to several months to have a clinically meaningful effect. This time lag to response constitutes a major burden for patients and contributes to increased morbidity and mortality. Two published studies in patients with MDD have now provided evidence for rapid and robust antidepressant efficacy o...

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De zwaargewonden eerst? Het Nederlandsche Roode Kruis en het vraagstuk van oorlog in vrede 1867–1945

emotional and intellectual rationales for the movement. At the same time he explores in meticulous detail the complicated practical politics involved. The heart of the story lies in the irony of the movement's survival, the success of the philanthropic effort to "civilize war" being met only through accommodation to, and then generous assistance of, the militaristic interests of individual nati...

The Mechanism of Toxicity in HET-S/HET-s Prion Incompatibility

The HET-s protein from the filamentous fungus Podospora anserina is a prion involved in a cell death reaction termed heterokaryon incompatibility. This reaction is observed at the point of contact between two genetically distinct strains when one harbors a HET-s prion (in the form of amyloid aggregates) and the other expresses a soluble HET-S protein (96% identical to HET-s). How the HET-s prio...

Pad e-type approximants and errors of Pad e approximants

The Brezinski’s idea of using Pad e-type approximants to estimate errors of Pad e approximants is considerably developed. A new, more e ective method based on this idea is presented and illustrated by numerical examples. c © 1998 Elsevier Science B.V. All rights reserved. AMS classi cation: 41A21